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| Drug Name |
SOTALOL HYDROCHLORIDE |
| Active Ingredient(s) |
SOTALOL HYDROCHLORIDE |
Form(s) and Strength(s) Available |
TABLET; ORAL:120MG ;160MG ;80MG |
Product Information / Press Release Sotalol is a non-selective beta-adrenergic receptor blocker without sympathomimetic activity or membrane stabilising activity. It causes a decrease in heart rate and a limited reduction in the force of contraction of the heart. There is a reduction in cardiac work and in myocardial oxygen demand. Sotalol does not decrease blood pressure in normotensive subjects.
Sotalol also possesses class III antiarrhythmic activity. Sotalol has no known effect on the upstroke velocity of the action potential, therefore no known effect on the depolarisation phase. Its major effects are prolongation of the atrial, ventricular and accessory pathway effective refractory periods. The effect on the ventricular myocardium may be reflected by a lengthening of the QTc interval on electrocardiographic recordings.
Like most other beta-blockers, sotalol inhibits renin release. This suppressive effect is significant both at rest and during exercise.
Manufacturers URL : www.tevausa.com
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